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GK24
General ScienceMediumAsked in: NDA · NDA-I 2025, GAT

A chain of peptide containing linear sequences of amino acid linked by peptide bonds best represent the

  1. A.Primary structure
  2. B.Secondary structure
  3. C.Tertiary structure
  4. D.Quaternary structure

Correct answer

A. Primary structure

Explanation

The correct answer is A, Primary structure. The primary structure of a protein is simply the linear order of amino acids joined one after another by peptide bonds.

Proteins are built at four levels. The primary structure is the sequence of amino acids in the polypeptide chain, fixed by the gene that codes for it. This sequence decides how the chain will fold later, so even a single change in it can alter the protein, as in sickle-cell anaemia where one amino acid of haemoglobin is replaced.

B is wrong because the secondary structure is the local folding of the chain into an alpha helix or a beta pleated sheet, held by hydrogen bonds. C is wrong because the tertiary structure is the overall three-dimensional folding of a whole chain. D is wrong because the quaternary structure is the arrangement of two or more polypeptide chains together, as in haemoglobin with its four subunits.

Exam tip: primary means sequence, secondary means helix or sheet, tertiary means 3-D fold, quaternary means several chains.

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